CBGA is otherwise known as Cannabigerolic Acid and is referenced as the “Mothership of all Cannabinoids”! As mentioned in the CBG article all other cannabinoids are derived from CBGA which is just an acidic form of CBG. When harvested cannabis has heat added to it CBGA will decarboxylate into CBG. A lot of the medicinal benefits in cannabis are possible due to this unique cannabinoid: CBGA!
CBGA is responsible for the production of three major cannabinoids: THCA or Tetrahydrocannabolic Acid, CBDA or Cannabidiolic Acid, and CBCA or Cannabichromenic Acid: these eventually become THC, CBD and CBC. Another unique quality of CBGA is that it has a protective function within the cannabis plant itself. CBGA Is produced in the plants trichomes, and it triggers a targeted plant cell death for natural leaf pruning specifically. This allows the plant to maximize its energy toward the flower!
Within the body, cannabinoids are compounds within cannabis that interact with a network of receptors in our body that we now know and love: the Endocannabinoid System! CBGA has been researched on its ability to act as an analgesic, antibacterial, anti-inflammatory, anti-proliferative, and more. Specific research has been done on CBGA’s ability to help diabetic patients combat symptoms and complications of the disease such as cardiovascular diseases. CBGA was found to greatly inhibit the enzyme aldose reductase which is a major contributor of oxidative stress that leads to heart and other problems.
CBGA may also help with metabolism regulation and can aid in metabolic disorders. Research was conducted in activating PPAR’s which are Peroxisome Proliferator Activated Receptors that are receptors that regulate metabolism. When these receptors don’t function properly people develop diseases like diabetes, high levels of cholesterol, etc. CBGA activated the PPAR receptors stimulating lipid metabolism and reducing excess lipid accumulation and is overall helpful for regulating your metabolism.
Lastly, CBGA has been researched into its effects on colon cancer! Specifically at the cytotoxic effects of CBGA extracted from cannabis which means its toxicity to living cells or cancer cells. It was found that it killed the colon cancer cells and even hastened early cancer cell death AND arrested the cancer cell cycle. This can also help prevent polyps and overall maintaining health cellular activity of the bowels, rectum, and colon.